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Literature summary for 3.5.1.23 extracted from

  • Doan, N.B.; Nguyen, H.S.; Al-Gizawiy, M.M.; Mueller, W.M.; Sabbadini, R.A.; Rand, S.D.; Connelly, J.M.; Chitambar, C.R.; Schmainda, K.M.; Mirza, S.P.
    Acid ceramidase confers radioresistance to glioblastoma cells (2017), Oncol. Rep., 38, 1932-1940 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Inhibitors

Inhibitors Comment Organism Structure
carmofur a specific ASAH1 inhibitor, inhibition by carmofur contributes to cytotoxicity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Homo sapiens
-
-
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
glioblastoma cell
-
 Homo sapiens
-
glioblastoma multiforme cancer stem cell
-
 Homo sapiens
-
SJGBM2 cell SJGBM2-10y cell medium, which is rich in secreted ASAH1, promotes 50% more cell growth than SJGBM2 medium containing a lower level of secreted ASAH1 Homo sapiens
-
U-87MG cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
acid ceramidase
-
 Homo sapiens
ASAH1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens irradiation induces expression of ASAH1 in glioblastoma multiforme cells, radiation induces oversecretion of ASAH1 up

General Information

General Information Comment Organism
malfunction upregulation of ASAH1 confers resistance to radiation by altering the sphingolipid metabolism pathway. ASAH1 plays a similar role in recurrent or irradiated glioblastoma multiforme. ASAH1 inhibition by camofur results in cell death and elevated levels of ceramides in U87, SJGBM2, U87-10gy and SJGBM2-10gy cells Homo sapiens
physiological function acid ceramidase (ASAH1), a lysosomal cysteine amidase, helps metabolize ceramides into sphingosine and free fatty acids. Ceramides promote senescence and apoptosis, while sphingososine-1-phospate (Sph-1P), the immediate metabolite of sphingosine, promotes cell survival, proliferation, inflammation, and angiogenesis. As such, overexpression of ASAH1 confers resistance to apoptosis Homo sapiens