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Literature summary for 3.5.1.23 extracted from

  • Zhang, C.H.; Zhang, M.J.; Shi, X.X.; Mao, C.; Zhu, Z.R.
    Alkaline ceramidase mediates the oxidative stress response in Drosophila melanogaster through sphingosine (2019), J. Insect Sci., 19, 13 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information generation of a Dacer-deficient Drosophila melanogaster mutant, which has higher catalase (CAT) activity and CAT transcription level, leading to higher resistance to oxidative stress induced by paraquat, quantitative proteomic analysis of wild-type and mutant cells. Three oxidoreductases, including two cytochrome P450 (CG3050, CG9438) and an oxoglutarate/iron-dependent dioxygenase (CG17807), are most significantly upregulated in the Dacer overexpressing mutant. Altered antioxidative activity in Dacer mutant might be responsible for increased oxidative stress resistance Drosophila melanogaster

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster M9PDG7
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-

Synonyms

Synonyms Comment Organism
alkaline ceramidase
-
 Drosophila melanogaster
bwa
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 Drosophila melanogaster
Dacer
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction a Dacer-deficient Drosophila melanogaster mutant has higher catalase (CAT) activity and CAT transcription level, leading to higher resistance to oxidative stress induced by paraquat. Altered antioxidative activity in Dacer mutant might be responsible for increased oxidative stress resistance. Quantitative proteomic analysis of wild-type and mutant cells. Three oxidoreductases, including two cytochrome P450 (CG3050, CG9438) and an oxoglutarate/iron-dependent dioxygenase (CG17807), are most significantly upregulated in the Dacer overexpressing mutant Drosophila melanogaster
physiological function enzyme Dacer regulates expression of oxidative stress proteins Drosophila melanogaster