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Literature summary for 3.5.1.23 extracted from

  • Baduva, K.; Buechter, L.; Kreyenkamp, K.; Westphal, L.; Wilker, B.; Kohnen, M.; Schuchman, E.H.; Edwards, M.J.; Becker, K.A.; Gulbins, E.; Carpinteiro, A.
    Signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines (2019), Cell. Physiol. Biochem., 52, 1092-1102 .
    View publication on PubMed
Search for more literature for 3.5.1.23

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Homo sapiens
-
 sphingosine + a fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Chang cell a conjunctiva epithelial cell line Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
T-lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
 Homo sapiens sphingosine + a fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
acid ceramidase
-
 Homo sapiens
ASAH1
-
 Homo sapiens
N-acylsphingosine aminohydrolase
-
 Homo sapiens

General Information

General Information Comment Organism
additional information treatment of cultured epithelial Chang cells or leukemic T-lymphocytes (Jurkat cells) with purified acid ceramidase results in a dose dependent activation of AKT, p38-kinase and p70S6-kinase, while tyrosine phosphorylation of intracellular proteins remains largely unchanged, determination of intracellular signalling events, proliferation and cell survival, overview. Acid ceramidase treatment does not change expression of tight junction proteins such as ZO-1, ZO-2 and occludin. Cellular viability and proliferation are not affected by acid ceramidase treatment Homo sapiens
physiological function signalling effects induced by acid ceramidase in human epithelial or leukemic cell lines Homo sapiens