Cloned (Comment) | Organism |
---|---|
radiation-induced acid ceramidase gene transactivation by activator protein 1 binding on the proximal promoter is sensitive to inhibition of de novo ceramide biosynthesis, as demonstrated by promoter reporter and ChIP-qPCR analyses | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LCL521 | a lysosomotropic prodrug inhibitor of acid ceramidase, inhibition in vivo leads to decreased cell viability | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13510 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
22Rv1 cell | - |
Homo sapiens | - |
DU-145 cell | - |
Homo sapiens | - |
PPC-1 cell | - |
Homo sapiens | - |
prostate cancer cell line | - |
Homo sapiens | - |
WPMY-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-hexanoyl-sphingosine + H2O | - |
Homo sapiens | hexanoate + sphingosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
- |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ionizing radiation selectively upregulates acid ceramidase in prostate cancer PCa cells, no induction of neutral and alkaline ceraamidases. Radiation-induced acid ceramidase gene transactivation by activator protein 1 binding on the proximal promoter is sensitive to inhibition of de novo ceramide biosynthesis, as demonstrated by promoter reporter and ChIP-qPCR analyses | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the influence of sphingolipids, such as ceramide and its metabolite sphingosine 1-phosphate, on signal transduction pathways under cell stress is important to survival adaptation responses. A protective feedback mechanism mitigates the apoptotic effect of ionizing radiation-induced ceramide generation. c-Jun-regulated acid veramidase mediates PCa cell radioresistance and relapse in vitro and in vivo | Homo sapiens |