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Literature summary for 3.5.1.23 extracted from

  • Bhabak, K.P.; Kleuser, B.; Huwiler, A.; Arenz, C.
    Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues (2013), Bioorg. Med. Chem., 21, 874-882.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R)-2-(N-tetradecanoylamino)-1-(4-nitrophenyl)-1,3-propanediol the efficacy of (1R,2R)-2-(N-tetradecanoylamino)-1-(4-nitrophenyl)-1,3-propanediol in vitro as well as in intact cells can be enhanced by suitable modification of functional groups; the efficacy of the inhibitor in vitro as well as in intact cells can be enhanced by suitable modification of functional groups Homo sapiens
(1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol
-
Homo sapiens
12-amino-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]dodecanamide
-
Homo sapiens
additional information structural modification of the known ceramidase inhibitors (1R,2R)-2-(N-tetradecanoylamino)-1-(4-nitrophenyl)-1,3-propanediol and N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]-12-(dimethylamino)dodecanamide generates more potent ceramidase inhibitors that are active in intact cells and not only elevates the cellular ceramide levels, but also enhances cell death Homo sapiens
N-(2-hydroxy-2-phenylethyl)tetradecanamide
-
Homo sapiens
N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]-12-(dimethylamino)dodecanamide
-
Homo sapiens
N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]tridecan-1-aminium chloride
-
Homo sapiens
N-[(1R,2R)-1,3-dihydroxy-1-phenylpropan-2-yl]tridecan-1-aminium chloride
-
Homo sapiens
N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-12-(1-methylhydrazinyl)dodecanamide
-
Homo sapiens
N-[(2R)-2-hydroxy-2-(pyridin-3-yl)ethyl]-12-(1-methylhydrazinyl)dodecanamide
-
Homo sapiens
N-[(2R)-2-hydroxy-2-(pyridin-4-yl)ethyl]-12-(1-methylhydrazinyl)dodecanamide
-
Homo sapiens
N-[2-hydroxy-2-(pyridin-3-yl)ethyl]-12-(1-methylhydrazinyl)dodecanamide
-
Homo sapiens
N-[2-hydroxy-2-(pyridin-3-yl)ethyl]tetradecanamide
-
Homo sapiens
N-[2-hydroxy-2-(pyridin-4-yl)ethyl]tetradecanamide
-
Homo sapiens
oleoylethanolamide i.e. N-oleylethanolamine; i.e. N-oleylethanolamine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510
-
-
Homo sapiens Q9NR71
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
aCDase
-
Homo sapiens
acid ceramidase
-
Homo sapiens
ASAH1
-
Homo sapiens
ASAH2
-
Homo sapiens
N-acylsphingosine amidohydrolase 2
-
Homo sapiens
nCDase
-
Homo sapiens
neutral ceramidase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.5
-
assay at Homo sapiens
7
-
assay at Homo sapiens