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Literature summary for 3.5.1.23 extracted from
- Novel off-target effect of tamoxifen - inhibition of acid ceramidase activity in cancer cells (2013), Biochim. Biophys. Acta, 1831, 1657-1664.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| lysosome | - |
Homo sapiens | 5764 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | acid ceramidase catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q13510 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| LoVo cell | - |
Homo sapiens | - |
| MDA-MB-231 cell | - |
Homo sapiens | - |
| MDA-MB-468 cell | - |
Homo sapiens | - |
| PANC-1 cell | - |
Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | acid ceramidase catalyzes the hydrolysis of ceramide to constituent sphingoid base, sphingosine, and fatty acid | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid ceramidase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
assay at | Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the prominent antiestrogen tamoxifen is a pan-effective acid ceramidase inhibitor in the low micromolar range, as demonstrated in a wide spectrum of cancer cell types, prostate, pancreatic, colorectal, and breast. Tamoxifen does not impact cell viability or inhibit the enzyme activity in cell-free assays. Mechanism of action via increases in lysosomal membrane permeability, and time- and dose-dependent downregulation of acid ceramidase protein expression, overview. The downregulation can be blocked by a cathepsin B inhibitor | down |
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Release 2023.1 (January 2023)
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