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Literature summary for 3.5.1.2 extracted from

  • Masson, J.; Darmon, M.; Conjard, A.; Chuhma, N.; Ropert, N.; Thoby-Brisson, M.; Foutz, A.S.; Parrot, S.; Miller, G.M.; Jorisch, R.; Polan, J.; Hamon, M.; Hen, R.; Rayport, S.
    Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth (2006), J. Neurosci., 26, 4660-4671.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
GLS1 gene, cloning from genomic library, quantitative expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information construction of GLS1-knockout mice using W9.5 embryonic stem ES cells and C57BL6/J blastocysts, mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth, the amplitude of inspirations is decreased in vivo, chemosensitivity to CO2 is severely altered, and the frequency of pacemaker activity recorded in the respiratory generator in the in vitro isolated pre-Boetzinger complex, a glutamatergic brainstem network, is increased, phenotypic characterization of GLS1 neonate mutant mice, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + H2O Mus musculus neurotransmitter glutamate has been thought to derive mainly from glutamine via the action of glutaminase type 1, the GLS1 pathway is essential for maintaining the function of active synapses, knockout mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth L-glutamate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain of newborn mice, and adult brain cortex and stem, GLS1 Mus musculus
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central nervous system GLS1 Mus musculus
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heart GLS1 Mus musculus
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kidney GLS1 Mus musculus
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liver neonatal liver, all GLS1 activity is caused by GLS1, which is downregulated during development, and supplanted by the liver-specific glutaminase type 2, GLS2, in adulthood Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
 Mus musculus L-glutamate + NH3
-
 ?
L-glutamine + H2O neurotransmitter glutamate has been thought to derive mainly from glutamine via the action of glutaminase type 1, the GLS1 pathway is essential for maintaining the function of active synapses, knockout mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth Mus musculus L-glutamate + NH3
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus