Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.2 extracted from

  • Romero-Gomez, M.; Ramos-Guerrero, R.; Grande, L.; de Teran, L.C.; Corpas, R.; Camacho, I.; Bautista, J.D.
    Intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy (2004), J. Hepatol., 41, 49-54.
    View publication on PubMed
Search for more literature for 3.5.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion phosphate-activated isozyme Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
phosphate phosphate-activated glutaminase isozyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + H2O Homo sapiens intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy, relationship between enzyme activity, liver function, and porto-systemic shunts, overview L-glutamate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
duodenum phosphate-activated isozyme, mucosa Homo sapiens
-
enterocyte phosphate-activated isozyme Homo sapiens
-
liver phosphate-activated isozyme, isozyme L-PAG Homo sapiens
-
small intestine phosphate-activated isozyme Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.68
-
 PAG, healthy liver tissue Homo sapiens
2.4
-
 PAG, cirrhotic disease patient liver tissue Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamine + H2O
-
 Homo sapiens L-glutamate + NH3
-
 ?
L-glutamine + H2O intestinal glutaminase activity is increased in liver cirrhosis and correlates with minimal hepatic encephalopathy, relationship between enzyme activity, liver function, and porto-systemic shunts, overview Homo sapiens L-glutamate + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PAG
-
 Homo sapiens
phosphate-activated glutaminase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens