Literature summary for 3.5.1.2 extracted from

Perez-Gomez, C.; Campos-Sandoval, J.A.; Alonso, F.J.; Segura, J.A.; Manzanares, E.; Ruiz-Sanchez, P.; Gonzalez, M.E.; Marquez, J.; Mates, J.M.
Co-expression of glutaminase K and L isoenzymes in human tumour cells (2005), Biochem. J., 386, 535-542.

Search for more literature for 3.5.1.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis of glutaminase isoenzymes in tumor cells by competitive RT-PCR, overview	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
glutamate	inhibits the enzyme in vivo in tumor cells at 100 mM	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
phosphate	activates the enzyme in vivo in tumor cells at 100 mM	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-glutamine + H2O	Homo sapiens	-	L-glutamate + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	two isozymes, glutaminase K and L, i.e. LGA and KGA	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood cell	of medullar blood of acute lymphoblastic leukaemia patients	Homo sapiens	-
Hep-G2 cell	hepatoblastoma cell line	Homo sapiens	-
KU812F cell	myeloid cell line	Homo sapiens	-
MCF-7 cell	breast cancer cell line	Homo sapiens	-
additional information	isozyme tissue distribution, co-expression of glutaminase K and L isoenzymes in human tumour cells, overview	Homo sapiens	-
ZR-75-1 cell	breast cancer cell line	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + H2O	-	Homo sapiens	L-glutamate + NH3	-	?

Synonyms

Synonyms	Comment	Organism
GA	-	Homo sapiens
glutaminase K	-	Homo sapiens
glutaminase L	-	Homo sapiens
KGA	-	Homo sapiens
kidney-type glutaminase	-	Homo sapiens
LGA	-	Homo sapiens
liver-type glutaminase	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Homo sapiens

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Release 2023.1 (January 2023)