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Literature summary for 3.5.1.2 extracted from

  • Michalik, M.; Nelson, J.; Erecinska, M.
    Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase (1992), Metabolism, 41, 1319-1326.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NH4+ no effect Rattus norvegicus
phosphate
-
Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
NH4+ no effect Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.07
-
Gln in presence of 50 mM phosphate Rattus norvegicus
2.42
-
Gln without phosphate Rattus norvegicus
2.6
-
L-Gln
-
Rattus norvegicus
2.6
-
Gln in presence of 10 mM phosphate Rattus norvegicus
2.63
-
Gln in presence of 100 mM phosphate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Gln + H2O Rattus norvegicus high glutaminase activity may be of importance for optimal insulin secretion elicited by amino acid secretagogues L-Glu + NH3
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HIT-T15 cell
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
pancreatic islet
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln + H2O
-
Rattus norvegicus Glu + NH3
-
?
L-Gln + H2O high glutaminase activity may be of importance for optimal insulin secretion elicited by amino acid secretagogues Rattus norvegicus L-Glu + NH3
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8 8.5
-
Rattus norvegicus