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Literature summary for 3.5.1.19 extracted from

  • Zhang, J.L.; Zheng, Q.C.; Li, Z.Q.; Zhang, H.X.
    Molecular dynamics simulations suggest ligands binding to nicotinamidase/pyrazinamidase (2012), PLoS ONE, 7, e39546.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.19

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure (PDB ID 2WT9) analysis, and modeling of substrate binding and unbinding, overview Acinetobacter baumannii
crystal structure (PDB ID 3O94) analysis, and modeling of substrate binding and unbinding, overview Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + H2O Streptococcus pneumoniae
-
 nicotinate + NH3
-
 ?
nicotinamide + H2O Acinetobacter baumannii
-
 nicotinate + NH3
-
 ?
pyrazinamide + H2O Streptococcus pneumoniae
-
 pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O Acinetobacter baumannii
-
 pyrazinoic acid + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii B0VA03 gene pncA
-
Streptococcus pneumoniae A0A0H2UR34
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + H2O
-
 Streptococcus pneumoniae nicotinate + NH3
-
 ?
nicotinamide + H2O
-
 Acinetobacter baumannii nicotinate + NH3
-
 ?
nicotinamide + H2O binding structure and unbinding mechanism, modeling, overview Streptococcus pneumoniae nicotinate + NH3
-
 ?
nicotinamide + H2O binding structure involving residues A155, C159, and Ile154, and unbinding mechanism, modeling, overview Acinetobacter baumannii nicotinate + NH3
-
 ?
pyrazinamide + H2O
-
 Streptococcus pneumoniae pyrazinoic acid + NH3
-
 ?
pyrazinamide + H2O
-
 Acinetobacter baumannii pyrazinoic acid + NH3
-
 ?

Synonyms

Synonyms Comment Organism
nicotinamidase/pyrazinamidase
-
 Acinetobacter baumannii
PncA
-
 Acinetobacter baumannii
pyrazinamidase
-
 Acinetobacter baumannii
PZAse
-
 Acinetobacter baumannii

General Information

General Information Comment Organism
additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure, PDB ID 3O94, the C136S mutation in 3O94 is restored to the wild-type Cys residue Streptococcus pneumoniae
additional information protein conformational changes after ligand dissociation, molecular dynamics simulation methods are performed to investigate the unbinding process of nicotinamide using the enzyme's crystal structure. PDB ID 2WT9 Acinetobacter baumannii