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Literature summary for 3.5.1.19 extracted from
- Reduced pyrazinamidase activity and the natural resistance of Mycobacterium kansasii to the antituberculois drug pyrazinamide (1999), Antimicrob. Agents Chemother., 43, 537-542.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Pyrazinamide | the natural resistance of Mycobacterium kansasii to pyrazinamide is due to a deficient pyrazinamidase activity of nicotinamidase | Mycobacterium kansasii |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium kansasii | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinamide + H2O | - |
Mycobacterium kansasii | nicotinate + NH3 | - |
? | |
| pyrazinamide + H2O | the natural resistance of Mycobacterium kansasii to pyrazinamide is due to a deficient pyrazinamidase activity of nicotinamidase | Mycobacterium kansasii | pyrazinoic acid + NH3 | - |
? | |
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Release 2023.1 (January 2023)
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