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Literature summary for 3.5.1.15 extracted from

  • Zhang, C.; Liu, X.; Xue, Y.
    A general acid-general base reaction mechanism for human brain aspartoacylase: A QM/MM study (2012), Comput. Theoret. Chem., 980, 85-91.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
R63N the mutation results in undetectable activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methylphosphonamidate
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the enzyme binds one zinc ion per monomer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P45381
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartate + H2O
-
Homo sapiens L-aspartate + acetate
-
ir

Synonyms

Synonyms Comment Organism
ASPA
-
Homo sapiens

General Information

General Information Comment Organism
malfunction the defect of aspartoacylase is the cause of Canavan disease Homo sapiens