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Literature summary for 3.5.1.15 extracted from
- Upregulation of N-acetylaspartic acid alters inflammation, transcription and contractile associated protein levels in the stomach and smooth muscle contractility (2009), Mol. Biol. Rep., 36, 201-206.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetylaspartic acid + H2O | Rattus norvegicus | - |
aspartate + acetate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| circular smooth muscle | - |
Rattus norvegicus | - |
| stomach | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetylaspartic acid + H2O | - |
Rattus norvegicus | aspartate + acetate | - |
? | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | enzyme deficiency is involved in Canavan disease and type 2 diabetes, high levels of N-acetylaspartic acid induce inflammatory agents TNFalpha, p38MAPK, iNOS, PKC, COX2 and ICAM3, and alters proteins levels and smooth muscle contractility, which contributes to the gastrointestinal disorder, overview | Rattus norvegicus |
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Release 2023.1 (January 2023)
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