Literature summary for 3.5.1.15 extracted from

Bitto, E.; Bingman, C.A.; Wesenberg, G.E.; McCoy, J.G.; Phillips, G.N.
Structure of aspartoacylase, the brain enzyme impaired in Canavan disease (2007), Proc. Natl. Acad. Sci. USA, 104, 456-461.

Search for more literature for 3.5.1.15

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Rattus norvegicus
expression in Escherichia coli	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
resolution 1.8 angstrom	Rattus norvegicus
resolution 2.8 Angstrom	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	necessary for activity	Rattus norvegicus
Zn2+	necessary for activity, coordinated by residues His-21, Glu-24, and His-116 and a phosphate	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-acetyl-L-aspartate + H2O	Rattus norvegicus	deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease	aspartate + acetate	-	?
N-acetyl-L-aspartate + H2O	Homo sapiens	deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease	aspartate + acetate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45381	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-L-aspartate + H2O	deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease	Rattus norvegicus	aspartate + acetate	-	?
N-acetyl-L-aspartate + H2O	deficiency in enzyme activity leads to spongiform degeneration of the white matter of the brain and is the established cause of Canavan disease	Homo sapiens	aspartate + acetate	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
aminoacylase 2	-	Rattus norvegicus
aminoacylase 2	-	Homo sapiens
ASPA	-	Rattus norvegicus
ASPA	-	Homo sapiens
Aspartoacylase	-	Rattus norvegicus
Aspartoacylase	-	Homo sapiens

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Release 2023.1 (January 2023)