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Literature summary for 3.5.1.15 extracted from

  • Barash, V.; Flhor, D.; Morag, B.; Boneh, A.; Elpeleg, O.N.; Gilon, C.
    A radiometric assay for aspartoacylase activity in human fibroblasts: application for the diagnosis of canavan's disease (1991), Clin. Chim. Acta, 201, 175-182.
    View publication on PubMed
Search for more literature for 3.5.1.15

Application

Application Comment Organism
medicine diagnosis of Canavan disease, an autosomal recessive neurodegenerative disorder characterized by aspartoacylase deficiency, technique for prenatal diagnosis Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8 2 N-acyl-L-aspartic acid
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-L-aspartic acid + H2O Homo sapiens
-
 acetate + aspartic acid
-
 ?
N-acetyl-L-aspartic acid + H2O Rattus norvegicus
-
 acetate + aspartic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-70°C, kept for up to 4 weeks without loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartic acid + H2O
-
 Homo sapiens acetate + aspartic acid
-
 ?
N-acetyl-L-aspartic acid + H2O
-
 Rattus norvegicus acetate + aspartic acid
-
 ?
N-acyl L-aspartic acid + H2O
-
 Homo sapiens acetate + L-aspartate
-
 ?
N-acyl L-aspartic acid + H2O
-
 Rattus norvegicus acetate + L-aspartate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Homo sapiens