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Literature summary for 3.5.1.14 extracted from

  • Newman, D.; Abuladze, N.; Scholz, K.; Dekant, W.; Tsuprun, V.; Ryazantsev, S.; Bondar, G.; Sassani, P.; Kurtz, I.; Pushkin, A.
    Specificity of aminoacylase III-mediated deacetylation of mercapturic acids (2007), Drug Metab. Dispos., 35, 43-50.
    View publication on PubMed
Search for more literature for 3.5.1.14

Activating Compound

Activating Compound Comment Organism Structure
DTT activates murine AAIII Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK293T cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
PCMB inhibits murine AAIII Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.28
-
 N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.3
-
 N-acetyl-S-(4-chlorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.3
-
 N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.4
-
 N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.5
-
 N-acetyl-S-(4-bromobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.6
-
 N-acetyl-S-(3-fluorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.8
-
 N-acetyl-S-(4-methoxybenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
0.9
-
 N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
1
-
 N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine 37°C, pH 7.5 Mus musculus
1.1
-
 N-acetyl-S-benzyl-L-cysteine 37°C, pH 7.5 Mus musculus
1.2
-
 N-acetyl-L-tryptophan 37°C, pH 7.5 Mus musculus
1.2
-
 N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine 37°C, pH 7.5 Mus musculus
1.3
-
 N-alpha-acetyl-L-lysine 37°C, pH 7.5 Mus musculus
1.3
-
 N-acetyl-S-(2-fluorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
1.4
-
 N-acetyl-L-tyrosine 37°C, pH 7.5 Mus musculus
1.45
-
 N-acetyl-S-(2-chlorobenzyl)-L-cysteine 37°C, pH 7.5 Mus musculus
1.6
-
 N-acetyl-L-phenylalanine 37°C, pH 7.5 Mus musculus
1.8
-
 N-acetyl-L-histidine 37°C, pH 7.5 Mus musculus
5.3
-
 N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine 37°C, pH 7.5 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
140000
-
 expressed in HEK293T cells Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q99JW2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-histidine + H2O
-
 Mus musculus acetate + L-histidine
-
 ?
N-acetyl-L-phenylalanine + H2O
-
 Mus musculus acetate + L-phenylalanine
-
 ?
N-acetyl-L-tryptophan + H2O
-
 Mus musculus acetate + L-tryptophan
-
 ?
N-acetyl-L-tyrosine + H2O
-
 Mus musculus acetate + L-tyrosine
-
 ?
N-acetyl-S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,1,2,2-tetrafluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,2-trichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2,3,4,4-pentachlorobutadienyl)-L-cysteine
-
 ?
N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(1,2-dichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichloro-1,1-difluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-dichlorovinyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-dichlorovinyl)-L-cysteine
-
 ?
N-acetyl-S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2,2-difluoro-1,1-dichloroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
 ?
N-acetyl-S-(2-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-chlorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(2-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(2-fluorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(3-fluorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(3-fluorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-bromobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-bromobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-chlorobenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-chlorobenzyl)-L-cysteine
-
 ?
N-acetyl-S-(4-methoxybenzyl)-L-cysteine + H2O
-
 Mus musculus acetate + S-(4-methoxybenzyl)-L-cysteine
-
 ?
N-acetyl-S-benzyl-L-cysteine + H2O
-
 Mus musculus acetate + S-benzyl-L-cysteine
-
 ?
N-alpha-acetyl-L-lysine + H2O
-
 Mus musculus acetate + L-lysine
-
 ?

Subunits

Subunits Comment Organism
homotetramer PAGE Mus musculus

Synonyms

Synonyms Comment Organism
AAIII
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
40
-
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
7.5 7.7
-
 Mus musculus