Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BW284c51 | dual site binder, interacts with PAS and the active site of acetylcholinesterase, thus inhibiting both the activities (esterase and aryl acylamidase) | Homo sapiens | |
additional information | by molecular docking studies the most favourable binding site of aryl acylamidase substrates and serotonin is identified as the side door of acetylcholinesterase. Propidium, a peripheral anionic site binder blocks the main door without affecting the side door, which explains its ineffectiveness in inhibiting aryl acylamidase | Homo sapiens | |
serotonin | serotonin inhibits aryl acylamidase while remaining ineffective against the esterase activity. It interacts with D74, N87, L76 and T83 residues of the side door | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22303 | cf. EC 3.1.1.7 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-nitroacetanilide + H2O | acetylcholinesterase exhibits two different activities: esterase and aryl acylamidase | Homo sapiens | 2-nitroaniline + acetate | - |
? | |
2-nitrotrifluoroacetanilide + H2O | acetylcholinesterase exhibits two different activities: esterase and aryl acylamidase | Homo sapiens | 2-nitroaniline + trifluoroacetic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAA | - |
Homo sapiens |