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Literature summary for 3.5.1.115 extracted from

  • Nicholas, G.M.; Eckman, L.L.; Newton, G.L.; Fahey, R.C.; Ray, S.; Bewley, C.A.
    Inhibition and kinetics of mycobacterium tuberculosis and Mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors (2003), Bioorg. Med. Chem., 11, 601-608.
    View publication on PubMed
Search for more literature for 3.5.1.115

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R,26S,27S)-2,27-diamino-1,3,26-trihydroxyoctacosan-13-one
-
 Mycobacterium tuberculosis
(2S,3R,26S,27S)-2,27-diamino-1,3,26-trihydroxyoctacosan-13-one
-
 Mycolicibacterium smegmatis
(2Z)-N-(4-amino-4-iminobutyl)-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
-
 Mycobacterium tuberculosis
(2Z)-N-(4-amino-4-iminobutyl)-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
-
 Mycolicibacterium smegmatis
(2Z)-N-[(2-amino-1H-imidazol-5-yl)methyl]-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
-
 Mycobacterium tuberculosis
(2Z)-N-[(2-amino-1H-imidazol-5-yl)methyl]-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
-
 Mycolicibacterium smegmatis
(5R,10S)-N-[2-(2-amino-1H-imidazol-5-yl)ethyl]-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
-
 Mycobacterium tuberculosis
(5R,10S)-N-[2-(2-amino-1H-imidazol-5-yl)ethyl]-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
-
 Mycolicibacterium smegmatis
1-pentyl-2-[10-(3-pentylpyridinium-1-yl)decyl]pyridinium
-
 Mycobacterium tuberculosis
1-pentyl-2-[10-(3-pentylpyridinium-1-yl)decyl]pyridinium
-
 Mycolicibacterium smegmatis
disodium 3-[(E)-2-carboxylatoethenyl]benzoate
-
 Mycobacterium tuberculosis
disodium 3-[(E)-2-carboxylatoethenyl]benzoate
-
 Mycolicibacterium smegmatis
gliotoxin mixed non-competitive inhibitor Mycobacterium tuberculosis
gliotoxin mixed non-competitive inhibitor Mycolicibacterium smegmatis
halisulfate 1
-
 Mycobacterium tuberculosis
halisulfate 1
-
 Mycolicibacterium smegmatis
oceanapiside low micromolar, non-competitive inhibitor Mycobacterium tuberculosis
oceanapiside low micromolar, non-competitive inhibitor Mycolicibacterium smegmatis
physcion
-
 Mycobacterium tuberculosis
physcion
-
 Mycolicibacterium smegmatis
psammaplysin A
-
 Mycobacterium tuberculosis
psammaplysin A
-
 Mycolicibacterium smegmatis
psammaplysin B
-
 Mycobacterium tuberculosis
psammaplysin B
-
 Mycolicibacterium smegmatis
S,S-dimethyl gliotoxin
-
 Mycobacterium tuberculosis
S,S-dimethyl gliotoxin
-
 Mycolicibacterium smegmatis
suvanine
-
 Mycobacterium tuberculosis
suvanine
-
 Mycolicibacterium smegmatis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a mycothiol S-conjugate + H2O Mycolicibacterium smegmatis
-
 an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
a mycothiol S-conjugate + H2O Mycobacterium tuberculosis
-
 an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycolicibacterium smegmatis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a mycothiol S-conjugate + H2O
-
 Mycolicibacterium smegmatis an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?
a mycothiol S-conjugate + H2O
-
 Mycobacterium tuberculosis an N-acetyl L-cysteine-S-conjugate + 1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol
-
 ?

Synonyms

Synonyms Comment Organism
MCA
-
 Mycolicibacterium smegmatis
MCA
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis 1-pentyl-2-[10-(3-pentylpyridinium-1-yl)decyl]pyridinium
0.0001
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis 1-pentyl-2-[10-(3-pentylpyridinium-1-yl)decyl]pyridinium
0.0005
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis oceanapiside
0.002
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis disodium 3-[(E)-2-carboxylatoethenyl]benzoate
0.002
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis (2Z)-N-(4-amino-4-iminobutyl)-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
0.003
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis disodium 3-[(E)-2-carboxylatoethenyl]benzoate
0.003
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis (2Z)-N-(4-amino-4-iminobutyl)-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
0.01
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis oceanapiside
0.02
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis psammaplysin B
0.03
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis psammaplysin A
0.03
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis psammaplysin A
0.03
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis psammaplysin B
0.03
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis (2Z)-N-[(2-amino-1H-imidazol-5-yl)methyl]-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
0.037
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis (2Z)-N-[(2-amino-1H-imidazol-5-yl)methyl]-3-[4-(3-aminopropoxy)-3,5-dibromophenyl]-2-(hydroxyimino)propanamide
0.04
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis halisulfate 1
0.05
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis gliotoxin
0.05
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis gliotoxin
0.05
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis physcion
0.05
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis (2S,3R,26S,27S)-2,27-diamino-1,3,26-trihydroxyoctacosan-13-one
0.06
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis suvanine
0.07
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis S,S-dimethyl gliotoxin
0.1
-
 at 31°C, pH not specified in the publication Mycolicibacterium smegmatis (5R,10S)-N-[2-(2-amino-1H-imidazol-5-yl)ethyl]-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
0.1
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis (5R,10S)-N-[2-(2-amino-1H-imidazol-5-yl)ethyl]-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide
0.1
-
 at 31°C, pH not specified in the publication Mycobacterium tuberculosis (2S,3R,26S,27S)-2,27-diamino-1,3,26-trihydroxyoctacosan-13-one