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Literature summary for 3.5.1.11 extracted from
- New active site oriented glyoxyl-agarose derivatives of Escherichia coli penicillin G acylase (2007), BMC Biotechnol., 7, 54.
Application
| Application | Comment | Organism |
|---|---|---|
| synthesis | immobilized penicillin G acylase derivatives are biocatalysts that are industrially used for the hydrolysis of Penicillin G by fermentation and for the kinetically controlled synthesis of semi-synthetic beta-lactam antibiotics. The desired orientation of immobilized enzyme with the active site freely accessible can be obtained by increasing the density of Lys residues on a predetermined region of the enzyme. The designed biocatalysts display improved synthetic performances and are able to maintain a similar activity to the free enzymes. The activity of the immobilized enzyme proportionally improves with the number of introduced Lys | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| penicillin G acylase | - |
Escherichia coli |
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Release 2023.1 (January 2023)
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