Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Acinetobacter baumannii | |
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Klebsiella pneumoniae | |
(2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Pseudomonas aeruginosa | |
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Acinetobacter baumannii | |
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Klebsiella pneumoniae | |
(2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | - |
Pseudomonas aeruginosa | |
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | - |
Acinetobacter baumannii | |
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | - |
Klebsiella pneumoniae | |
(2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | - |
Pseudomonas aeruginosa | |
meropenem | - |
Acinetobacter baumannii | |
meropenem | - |
Klebsiella pneumoniae | |
meropenem | - |
Pseudomonas aeruginosa | |
additional information | evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview | Acinetobacter baumannii | |
additional information | evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview | Klebsiella pneumoniae | |
additional information | evaluation of LpxC inhibitors that are potent and rapidly bactericidal against multiple Gram-negative species, overview | Pseudomonas aeruginosa | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Acinetobacter baumannii | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Klebsiella pneumoniae | |
N-[(2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide | - |
Pseudomonas aeruginosa |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter baumannii | - |
different isolates, gene lpxC | - |
Klebsiella pneumoniae | - |
different isolates, gene lpxC | - |
Pseudomonas aeruginosa | - |
and different isolates, gene lpxC | - |
Synonyms | Comment | Organism |
---|---|---|
LpxC | - |
Pseudomonas aeruginosa |
LpxC | - |
Klebsiella pneumoniae |
LpxC | - |
Acinetobacter baumannii |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Pseudomonas aeruginosa |
37 | - |
assay at | Klebsiella pneumoniae |
37 | - |
assay at | Acinetobacter baumannii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Pseudomonas aeruginosa |
7.4 | - |
assay at | Klebsiella pneumoniae |
7.4 | - |
assay at | Acinetobacter baumannii |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000000069 | - |
pH 7.4, 37°C | Klebsiella pneumoniae | (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.00000068 | - |
pH 7.4, 37°C | Klebsiella pneumoniae | (2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | |
0.000001 | - |
pH 7.4, 37°C | Klebsiella pneumoniae | (2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.0000011 | - |
wild-type, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.0000014 | - |
wild-type, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.0000021 | - |
mutant M62R, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.0000028 | - |
mutant M62R, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | |
0.0000036 | - |
wild-type, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | |
0.0000079 | - |
mutant M62R, pH 7.4, 37°C | Pseudomonas aeruginosa | (2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.000041 | - |
pH 7.4, 37°C | Acinetobacter baumannii | (2R)-4-([1,1'-biphenyl]-4-yl)-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide | |
0.00011 | - |
pH 7.4, 37°C | Acinetobacter baumannii | (2R)-N-hydroxy-2-(methanesulfonyl)-2-methyl-4-(2-oxo-4-phenylpyridin-1(2H)-yl)butanamide | |
0.000183 | - |
pH 7.4, 37°C | Acinetobacter baumannii | (2R)-4-[4-(2-fluoro-4-methoxyphenyl)-2-oxopyridin-1(2H)-yl]-N-hydroxy-2-(methanesulfonyl)-2-methylbutanamide |