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Literature summary for 3.5.1.1 extracted from

  • Appel, I.M.; Hop, W.C.; Pieters, R.
    Changes in hypercoagulability by asparaginase: a randomized study between two asparaginases (2006), Blood Coagul. Fibrinolysis, 17, 139-146.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is used for acute lymphoblastic leukemia treatment, the enzyme does not reduces alpha-antiplasmin and plasminogen levels in human patients, overview Dickeya chrysanthemi
medicine the enzyme is used for acute lymphoblastic leukemia treatment, the enzyme reduces alpha-antiplasmin and plasminogen levels in human patients, this together with the elevated level of thrombin activity in the patients lead to an enhanced risk for thrombosis due to delay in fibrin elimination in Escherichia coli L-asparaginase-treated patients, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-asparagine + H2O Dickeya chrysanthemi the enzyme does not reduce alpha-antiplasmin and plasminogen levels in human patients with acute lymphoblastic leukemia L-aspartate + NH3
-
?
L-asparagine + H2O Escherichia coli the enzyme reduces alpha-antiplasmin and plasminogen levels in human patients with acute lymphoblastic leukemia L-aspartate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Dickeya chrysanthemi
-
-
-
Escherichia coli
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Escherichia coli
-
commercial preparation
-
Dickeya chrysanthemi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-asparagine + H2O
-
Escherichia coli L-aspartate + NH3
-
?
L-asparagine + H2O
-
Dickeya chrysanthemi L-aspartate + NH3
-
?
L-asparagine + H2O the enzyme does not reduce alpha-antiplasmin and plasminogen levels in human patients with acute lymphoblastic leukemia Dickeya chrysanthemi L-aspartate + NH3
-
?
L-asparagine + H2O the enzyme reduces alpha-antiplasmin and plasminogen levels in human patients with acute lymphoblastic leukemia Escherichia coli L-aspartate + NH3
-
?

Synonyms

Synonyms Comment Organism
Erwinase
-
Dickeya chrysanthemi
L-asparaginase
-
Escherichia coli
L-asparaginase
-
Dickeya chrysanthemi