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Literature summary for 3.5.1.1 extracted from

  • Wriston, J.C.; Yellin, T.O.
    L-Asparaginase: a review (1973), Adv. Enzymol. Relat. Areas Mol. Biol., 39, 185-248.
    View publication on PubMed

General Stability

General Stability Organism
reversibly dissociated by urea Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
5-Diazo-4-oxo-L-norvaline
-
Escherichia coli
L-Asn inhibits hydrolysis of diazo-4-oxo-L-norvaline Escherichia coli
L-Asp product inhibition at pH 8.5 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0048
-
Asn
-
Acinetobacter calcoaceticus
0.0058
-
Gln
-
Acinetobacter calcoaceticus
0.0095
-
diazo-4-oxo-L-norvaline
-
Escherichia coli
0.01
-
L-asparagine
-
Pectobacterium carotovorum
0.0115
-
Asn
-
Escherichia coli
0.0125
-
L-asparagine
-
Escherichia coli
0.026
-
L-asparagine
-
Proteus vulgaris
0.03
-
Asn
-
Cupriavidus necator
0.04
-
L-Gln
-
Cupriavidus necator
0.06
-
Asn
-
Gallus gallus
0.072
-
L-asparagine
-
Cavia porcellus
0.1
-
L-asparagine
-
Serratia marcescens
0.5
-
L-asparagine
-
Fusarium tricinctum
1.1
-
Gln
-
Pectobacterium carotovorum
3
-
L-Asn
-
Acinetobacter calcoaceticus
3
-
L-Asn
-
Erwinia aroidea
4.7
-
Asn
-
Weizmannia coagulans
6.26
-
Gln
-
Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
-
Escherichia coli
85000
-
sucrose density gradient centrifugation Weizmannia coagulans
97000
-
gel filtration Acinetobacter glutaminasificans
100000 120000 gel filtration Escherichia coli
118000
-
gel filtration Pseudomonas sp.
122000
-
ultracentrifugation Pseudomonas sp.
130000
-
-
Acinetobacter calcoaceticus
130000
-
ultracentrifugation Escherichia coli
130000
-
ultracentrifugation Acinetobacter glutaminasificans
133000
-
gel filtration Cavia porcellus
135000
-
ultracentrifugation Pectobacterium carotovorum
138000
-
ultracentrifugation Cavia porcellus
147000
-
ultracentrifugation Serratia marcescens
150000
-
sucrose density gradient centrifugation Serratia marcescens
150000
-
ultracentrifugation Cupriavidus necator
306000
-
gel filtration Gallus gallus

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
-
-
Acinetobacter glutaminasificans
-
-
-
Aspergillus niger
-
-
-
Aspergillus oryzae
-
-
-
Aspergillus terreus
-
-
-
Azotobacter agilis
-
-
-
Brucella abortus
-
-
-
Cavia porcellus
-
-
-
Clostridium cadaveris
-
-
-
Cupriavidus necator
-
-
-
Erwinia aroidea
-
-
-
Escherichia coli
-
K-12
-
Escherichia coli
-
EC-I
-
Escherichia coli EC-I
-
EC-I
-
Fusarium tricinctum
-
-
-
Gallus gallus
-
-
-
Geobacillus stearothermophilus
-
-
-
Lablab purpureus
-
-
-
Lupinus luteus
-
-
-
Mycobacterium avium
-
-
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis variant bovis
-
-
-
Mycolicibacterium phlei
-
-
-
Mycolicibacterium smegmatis
-
-
-
Neurospora crassa
-
-
-
Pectobacterium carotovorum
-
-
-
Platyrrhini
-
new world
-
Proteus vulgaris
-
-
-
Pseudomonas fluorescens
-
-
-
Pseudomonas sp.
-
P-210
-
Pseudomonas sp.
-
GG13
-
Pseudomonas sp. GG13
-
GG13
-
Pseudomonas sp. P-210
-
P-210
-
Rattus norvegicus
-
-
-
Saccharomyces cerevisiae
-
-
-
Salmonella typhosa
-
-
-
Serratia marcescens
-
-
-
Staphylococcus sp.
-
-
-
Streptomyces griseus
-
-
-
Weizmannia coagulans
-
-
-
[Pseudomonas] boreopolis
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-
liver
-
Cavia porcellus
-
serum
-
Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyloxycarbonyl-Gly-L-Asn + H2O
-
Pectobacterium carotovorum benzyloxycarbonyl-Gly-L-Asp
-
?
beta-aspartoethylamide + H2O at 0.4% of the activity with L-Asn Pectobacterium carotovorum ?
-
?
beta-aspartomethylamide + H2O at 0.5% of the activity with L-Asn Pectobacterium carotovorum L-Asp + ethylamine
-
?
beta-aspartopropylamide + H2O at 0.7% of the activity with L-Asn Pectobacterium carotovorum ?
-
?
beta-cyano-L-Ala + H2O beta-cyano-L-Ala Cavia porcellus ?
-
?
beta-cyano-L-Ala + H2O beta-cyano-L-Ala Escherichia coli ?
-
?
beta-cyano-L-Ala + H2O beta-cyano-L-Ala Pectobacterium carotovorum ?
-
?
beta-cyano-L-Ala + H2O at 5.7% of the activity with L-Asn Pectobacterium carotovorum ?
-
?
beta-cyano-L-Ala + H2O at 2.4% of the activity with L-Asn Escherichia coli ?
-
?
beta-cyano-L-Ala + H2O beta-cyano-L-Ala Escherichia coli EC-I ?
-
?
beta-cyano-L-Ala + H2O at 2.4% of the activity with L-Asn Escherichia coli EC-I ?
-
?
D-Asn + H2O
-
Cavia porcellus D-Asp + NH3
-
?
D-Asn + H2O
-
Proteus vulgaris D-Asp + NH3
-
?
D-Asn + H2O
-
Weizmannia coagulans D-Asp + NH3
-
?
D-Asn + H2O at 5% of the activity with L-Asn Escherichia coli D-Asp + NH3
-
?
D-Asn + H2O at 5% of the activity with L-Asn Acinetobacter calcoaceticus D-Asp + NH3
-
?
D-Asn + H2O at 5% of the activity with L-Asn Pectobacterium carotovorum D-Asp + NH3
-
?
D-Asn + H2O at 5% of the activity with L-Asn Escherichia coli EC-I D-Asp + NH3
-
?
diazo-4-oxo-L-norvaline + H2O
-
Escherichia coli 5-hydroxy-4-oxo-L-norvaline + NH3
-
?
DL-Ala-DL-Asn + H2O
-
Pectobacterium carotovorum DL-Ala-DL-Asn + DL-Ala-DL-Asp 75% Ala-Asp + 25% Ala-Asn ?
DL-aspartyl hydroxamate + H2O
-
Pectobacterium carotovorum DL-Asp + hydroxylamine
-
?
Gly-D-Asn + H2O
-
Pectobacterium carotovorum Gly-D-Asp + NH3
-
?
Gly-L-Asn + H2O
-
Pectobacterium carotovorum Gly-L-Asp + NH3
-
?
L-Asn + H2O
-
Gallus gallus L-Asp + NH3
-
?
L-Asn + H2O
-
Cavia porcellus L-Asp + NH3
-
?
L-Asn + H2O
-
Escherichia coli L-Asp + NH3
-
?
L-Asn + H2O
-
Rattus norvegicus L-Asp + NH3
-
?
L-Asn + H2O
-
Saccharomyces cerevisiae L-Asp + NH3
-
?
L-Asn + H2O
-
Mycolicibacterium smegmatis L-Asp + NH3
-
?
L-Asn + H2O
-
Lupinus luteus L-Asp + NH3
-
?
L-Asn + H2O
-
Geobacillus stearothermophilus L-Asp + NH3
-
?
L-Asn + H2O
-
Neurospora crassa L-Asp + NH3
-
?
L-Asn + H2O
-
Aspergillus niger L-Asp + NH3
-
?
L-Asn + H2O
-
Pseudomonas fluorescens L-Asp + NH3
-
?
L-Asn + H2O
-
Pseudomonas sp. L-Asp + NH3
-
?
L-Asn + H2O
-
Acinetobacter calcoaceticus L-Asp + NH3
-
?
L-Asn + H2O
-
Serratia marcescens L-Asp + NH3
-
?
L-Asn + H2O
-
Brucella abortus L-Asp + NH3
-
?
L-Asn + H2O
-
Mycolicibacterium phlei L-Asp + NH3
-
?
L-Asn + H2O
-
Mycobacterium avium L-Asp + NH3
-
?
L-Asn + H2O
-
Proteus vulgaris L-Asp + NH3
-
?
L-Asn + H2O
-
Mycobacterium tuberculosis L-Asp + NH3
-
?
L-Asn + H2O
-
Platyrrhini L-Asp + NH3
-
?
L-Asn + H2O
-
Weizmannia coagulans L-Asp + NH3
-
?
L-Asn + H2O
-
Staphylococcus sp. L-Asp + NH3
-
?
L-Asn + H2O
-
Cupriavidus necator L-Asp + NH3
-
?
L-Asn + H2O
-
Streptomyces griseus L-Asp + NH3
-
?
L-Asn + H2O
-
Pectobacterium carotovorum L-Asp + NH3
-
?
L-Asn + H2O
-
Aspergillus oryzae L-Asp + NH3
-
?
L-Asn + H2O
-
Aspergillus terreus L-Asp + NH3
-
?
L-Asn + H2O
-
Mycobacterium tuberculosis variant bovis L-Asp + NH3
-
?
L-Asn + H2O
-
Erwinia aroidea L-Asp + NH3
-
?
L-Asn + H2O
-
Azotobacter agilis L-Asp + NH3
-
?
L-Asn + H2O
-
Fusarium tricinctum L-Asp + NH3
-
?
L-Asn + H2O
-
Clostridium cadaveris L-Asp + NH3
-
?
L-Asn + H2O
-
Salmonella typhosa L-Asp + NH3
-
?
L-Asn + H2O
-
Lablab purpureus L-Asp + NH3
-
?
L-Asn + H2O
-
Acinetobacter glutaminasificans L-Asp + NH3
-
?
L-Asn + H2O
-
[Pseudomonas] boreopolis L-Asp + NH3
-
?
L-Asn + H2O
-
Escherichia coli EC-I L-Asp + NH3
-
?
L-Asn + H2O
-
Pseudomonas sp. P-210 L-Asp + NH3
-
?
L-Asn + H2O
-
Pseudomonas sp. GG13 L-Asp + NH3
-
?
L-Gln + H2O
-
Acinetobacter calcoaceticus L-Glu + NH3
-
?
L-Gln + H2O
-
Proteus vulgaris L-Glu + NH3
-
?
L-Gln + H2O at 9% of the activity with L-Asn Pectobacterium carotovorum L-Glu + NH3
-
?
L-Gln + H2O at 4% of the activity with L-asparagine Escherichia coli L-Glu + NH3
-
?
L-Gln + H2O at 4% of the activity with L-asparagine Escherichia coli EC-I L-Glu + NH3
-
?
L-Gln + H2O
-
Cupriavidus necator ?
-
?
L-Gln-L-Asn + H2O
-
Pectobacterium carotovorum L-Gln-L-Asp + NH3
-
?
L-Glu-L-Asn + H2O
-
Pectobacterium carotovorum L-Glu-L-Asp + NH3
-
?
succinamic acid + H2O at 20% of the activity with L-Asn Pectobacterium carotovorum ?
-
?

Subunits

Subunits Comment Organism
More
-
Escherichia coli