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Literature summary for 3.4.99.B1 extracted from

  • Wahlstrom, A.M.; Cutts, B.A.; Karlsson, C.; Andersson, K.M.; Liu, M.; Sjogren, A.K.; Swolin, B.; Young, S.G.; Bergo, M.O.
    Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease (2007), Blood, 109, 763-768.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus in the absence of Rce1, splenocytes and bone marrow cells expressing oncogenic KRAS yield more and larger colonies when grown in methylcellulose. The inactivation of Rce1 worsens the myeloproliferative disease caused by oncogenic K-RAS ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
hematopoietic cell the inactivation of Rce1 actually increases peripheral leukocytosis, increases the release of immature hematopoietic cells into the circulation and the infiltration of cells into liver and spleen, and causes mice to die more rapidly Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in the absence of Rce1, splenocytes and bone marrow cells expressing oncogenic KRAS yield more and larger colonies when grown in methylcellulose. The inactivation of Rce1 worsens the myeloproliferative disease caused by oncogenic K-RAS Mus musculus ?
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 ?