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Literature summary for 3.4.25.2 extracted from

  • Kuo, M.S.; Chen, K.P.; Wu, W.F.
    Regulation of RcsA by the ClpYQ (HslUV) protease in Escherichia coli (2004), Microbiology, 150, 437-446.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
genes clpQ and clpY, DNA sequence determination, overexpression in a Lon protease-deficient mutant strain suppresses expression of the cps gene and of mucoid phenotype Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RcsA + H2O Escherichia coli specific substrate degradation, the enzyme is involved in regulation of RcsA, a capsule synthesis activator, the ClpYQ protease acts as a secondary protease in degrading the Lon protease substrate RscA ?
-
?
SulA + H2O Escherichia coli specific substrate degradation ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
genes clpQ and clpY of the clpQ+ clpY+ operon
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RcsA + H2O specific substrate degradation, the enzyme is involved in regulation of RcsA, a capsule synthesis activator, the ClpYQ protease acts as a secondary protease in degrading the Lon protease substrate RscA Escherichia coli ?
-
?
RcsA + H2O specific substrate degradation, the enzyme is involved in regulation of RcsA, a capsule synthesis activator Escherichia coli ?
-
?
SulA + H2O specific substrate degradation Escherichia coli ?
-
?
SulA + H2O specific substrate degradation, the substrate is a cell division inhibitor Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
hexamer self-oligomerization of each ClpQ and ClpY, four hexamers constitute a dumb-bell-shaped complex ina Y6Q6Q6Y6 configuration Escherichia coli

Synonyms

Synonyms Comment Organism
ClpYQ protease
-
Escherichia coli
HslUV protease
-
Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli