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Literature summary for 3.4.25.2 extracted from
- Determination of the cleavage sites in SulA, a cell division inhibitor, by the ATP-dependent HslVU protease from Escherichia coli (2003), FEBS Lett., 553, 351-354.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| phenylmethylsulfonyl fluoride | - |
Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SulA + H2O | Escherichia coli | - |
additional information | the enzyme produces 58 peptides with various sizes, 3-31 residues | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| SulA + H2O | - |
Escherichia coli | additional information | the enzyme produces 58 peptides with various sizes, 3-31 residues | ? | |
| SulA + H2O | the central and the C-terminal regions are preferentially cleaved. Major cleavage sites: Ala80-Ser81, Ala150-Ser151, Leu54-Gln55, Ile163-His164, Leu67-Thr68, Leu49-Leu50, Leu65-Trp66. No cleavage in absence of ATP | Escherichia coli | additional information | the enzyme produces 58 peptides with various sizes, 3-31 residues | ? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | no cleavage of SulA in absence of ATP | Escherichia coli | |
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