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Literature summary for 3.4.25.1 extracted from

  • Clerc, J.; Groll, M.; Illich, D.J.; Bachmann, A.S.; Huber, R.; Schellenberg, B.; Dudler, R.; Kaiser, M.
    Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition (2009), Proc. Natl. Acad. Sci. USA, 106, 6507-6512.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.25.1

Inhibitors

Inhibitors Comment Organism Structure
glidobactin A GlbA Homo sapiens
additional information syrbactins, a family of natural products produced by strains of the plant pathogen Pseudomonas syringae pv. syringae, that belong either to the syringolin or glidobactin class, are highly potent proteasome inhibitors Homo sapiens
N2-(decylcarbamoyl)-N-[(3E,5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododeca-3,9-dien-8-yl]-L-valinamide rational design and synthesis of a syringolin A-based lipophilic derivative, which proves to be a very potent syrbactin-based proteasome inhibitor Homo sapiens
syringolin A SylA, synthesis and inhibitory potency, overview Homo sapiens
syringolin A methyl ester
-
 Homo sapiens
syringolin B SylB, synthesis and inhibitory potency, overview Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
20S proteasome
-
 Homo sapiens
proteasome
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000865
-
 for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens N2-(decylcarbamoyl)-N-[(3E,5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododeca-3,9-dien-8-yl]-L-valinamide
0.000049
-
 for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens glidobactin A
0.0000796
-
 for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens N2-(decylcarbamoyl)-N-[(3E,5S,8S,9E)-2,7-dioxo-5-(propan-2-yl)-1,6-diazacyclododeca-3,9-dien-8-yl]-L-valinamide
0.000757
-
 for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin A methyl ester
0.00102
-
 for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin A
0.002
-
 for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens glidobactin A
0.00778
-
 for the chymotrypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin B
0.0103
-
 for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin A
0.0187
-
 for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin A methyl ester
0.1078
-
 for the trypsin-like activity, pH not specified in the publication, temperature not specified in the publication Homo sapiens syringolin B