Activating Compound | Comment | Organism | Structure |
---|---|---|---|
nuclear factor erythroid-derived 2-related factor 1 | i.e. Nrf1, a transcription factor of the cap and collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in cancer cell lines, overview | Homo sapiens | |
nuclear factor erythroid-derived 2-related factor 1 | i.e. Nrf1, a transcription factor of the cap and collar basic leucine zipper family, but not the related Nrf2, is necessary for induced proteasome gene transcription in mouse embryonic fibroblasts, overview. Knockdown of Nrf1 in wild-type mouse embryonic fibroblasts abolishes MG132-mediated upregulation of RNA levels of PSM genes | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | Nrf1-mediated proteasome homeostasis can be an attractive target for therapeutic intervention in cancer | Mus musculus |
medicine | Nrf1-mediated proteasome homeostasis can be an attractive target for therapeutic intervention in cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bortezomib | - |
Homo sapiens | |
MG132 | - |
Homo sapiens | |
Yu101 | - |
Homo sapiens | |
Yu101 | Nrf1-/- mouse embryonic fibroblasts are impaired in the recovery of proteasome activity after transient treatment with the covalent proteasome inhibitor YU101 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic fibroblast | - |
Mus musculus | - |
HT-29 cell | colon cancer cell line | Homo sapiens | - |
LNCaP cell | prostate cancer cell line | Homo sapiens | - |
MDA-MB-231 cell | breast cancer cell line | Homo sapiens | - |
U2-OS cell | osteosarcoma cell line | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
26S proteasome | - |
Mus musculus |
26S proteasome | - |
Homo sapiens |
proteasome | - |
Mus musculus |
proteasome | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes | up |
Homo sapiens | importance of antioxidant response elements in Nrf1-mediated upregulation of proteasome subunit genes | up |
General Information | Comment | Organism |
---|---|---|
additional information | proteasome inhibitors, but not a Nedd8 pathway inhibitor, upregulate RNA levels of PSM genes in cancer cells | Homo sapiens |