Literature summary for 3.4.25.1 extracted from

Basler, M.; Lauer, C.; Beck, U.; Groettrup, M.
The proteasome inhibitor bortezomib enhances the susceptibility to viral infection (2009), J. Immunol., 183, 6145-6150.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bortezomib	proteasome inhibition with bortezomib led to an increased susceptibility to viral infection, e.g. with lymphocytic choriomeningitis virus, and proteasome inhibitors can alter Ag processing in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	C57BL/6 mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MC57 cell	a C57BL/6-derived methylcholantrene-induced fibrosarcoma cell line	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
proteasome	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	the proteasome, a multicatalytic protease, is responsible for the generation of most MHC class I ligands	Mus musculus

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Release 2023.1 (January 2023)