Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epoxomicin | - |
Homo sapiens | |
MG132 | - |
Homo sapiens | |
additional information | screening of compounds for in vitro capacity to inhibit the chymotryptic-, tryptic-like, and post-acidic activities of the proteasome, overview. Detection of N-terminal-prolonged vinyl ester-based peptides as selective proteasome beta1 subunit inhibitors. The inhibitors demonstrate resistance to plasmatic proteases and a good capacity to permeate the cell membrane, but low inhibitory potencies. Inhibitors of the post-acidic activity of proteasomes neither induce cell death nor greatly inhibit cell proliferation | Homo sapiens | |
Z-b-Ala-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-beta-Ala-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-Gly-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-Gly-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)3-CO-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)3-CO-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)4-CO-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)4-CO-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)5-CO-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)5-CO-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)6-CO-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)6-CO-Val-Ser-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)7-CO-Leu-Leu-Leu-vinyl ester | - |
Homo sapiens | |
Z-NH-(CH2)7-CO-Val-Ser-Leu-vinyl ester | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphoblastoid cell line | - |
Homo sapiens | - |
mononuclear cell | from peripheral blood | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-LRR-4-methyl-7-amido-coumarin + H2O | trypsin-like proteasome activity | Homo sapiens | benzoyl-LRR + 4-methyl-7-amino-coumarin | - |
? | |
N-succinyl-LLVY-7-amido-4-methylcoumarin + H2O | chymotrypsin-like proteasome activity | Homo sapiens | N-succinyl-LLVY + 7-amino-4-methylcoumarin | - |
? | |
Z-LLE-4-methyl-7-amido-coumarin + H2O | post-acidic proteasome activity | Homo sapiens | Z-LLE + 4-methyl-7-amino-coumarin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
multi-subunit protease complex | - |
Homo sapiens |
proteasome | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | the barrel-shaped proteolytic 20S proteasome core particle which consists of four seven-subunit rings, is capped at one or both ends by 19S regulatory particles and is the central part of the large, 2.4 MDa, multi-subunit protease complexes performing ATP-dependent degradation of poly-ubiquitinated proteins, and being responsible for the majority of the non-lysosomal proteolysis which occurs in eukaryotic cells | Homo sapiens |