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Literature summary for 3.4.25.1 extracted from

  • Miura, Y.; Sakurai, Y.; Hayakawa, M.; Shimada, Y.; Zempel, H.; Sato, Y.; Hisanaga, S.; Endo, T.
    Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes (2010), Biol. Pharm. Bull., 33, 22-28.
    View publication on PubMed
Search for more literature for 3.4.25.1

Inhibitors

Inhibitors Comment Organism Structure
lactacystin
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Rattus norvegicus
-
brain
-
 Rattus norvegicus
-
neuron primary culture Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
proteasome
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function oxidative stress caused by tert-butyl hydroperoxide and proteasome inhibition by lactacystin induce apoptosis in neurons and astrocytes. Suppression of proteasome activity triggers the translocation of cathepsin D from lysosomes to cytosol, mechanism, overview Rattus norvegicus