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Literature summary for 3.4.25.1 extracted from

  • Groll, M.; Berkers, C.R.; Ploegh, H.L.; Ovaa, H.
    Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome (2006), Structure, 14, 451-456.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with bortezomib, hanging drop vapour diffusion method at 24°C in 30 mM MgOAc, 100 mM MES (pH 7.2), and 10% 2-methyl-2,4-pentanediol Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
bortezomib also termed VELCADE Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzyl-Val-Gly-Arg-7-amido-4-methylcoumarin + H2O
-
Saccharomyces cerevisiae ?
-
?
benzyloxycarbonyl-Leu-Leu-Glu-beta-naphthylamide + H2O
-
Saccharomyces cerevisiae ?
-
?
succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
-
Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
20S proteasome
-
Saccharomyces cerevisiae