Literature summary for 3.4.25.1 extracted from

Fu, Y.; Xu, B.; Zou, X.; Ma, C.; Yang, X.; Mou, K.; Fu, G.; Lue, Y.; Xu, P.
Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 1102-1106.

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Inhibitors

Inhibitors	Comment	Organism	Structure
MG132	0.001 mM	Homo sapiens
N-[(1S)-1-benzyl-2-[[(1S)-1-(furan-2-ylcarbonyl)-3-methylbutyl]amino]-2-oxoethyl]-Na-(tert-butoxycarbonyl)-L-phenylalaninamide	inhibits chymotrypsin-like activity of the 26S proteasome	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-
HL-60 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
26S proteasome	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00785	-	-	Homo sapiens	N-[(1S)-1-benzyl-2-[[(1S)-1-(furan-2-ylcarbonyl)-3-methylbutyl]amino]-2-oxoethyl]-Na-(tert-butoxycarbonyl)-L-phenylalaninamide

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Release 2023.1 (January 2023)