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Literature summary for 3.4.25.1 extracted from
- Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes (2006), Arch. Biochem. Biophys., 453, 135-142.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxy-2-nonenal | specific subunits of the 20S proteasome are targeted for modification by 4-hydroxy-2-nonenal (0.5 mM) | Rattus norvegicus |  |
| N-Cbz-Leu-Leu-leucinal | MG132 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| DEAE column chromatography, MonoQ HR5/5 column chromatography, and Superose 6 gel filtration | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-Cbz-Leu-Leu-Glu-beta-naphthylamide + H2O | - |
Rattus norvegicus | ? | - |
? | |
| N-t-Boc-Leu-Ser-Thr-Arg-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 20S proteasome | - |
Rattus norvegicus |
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