Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CL-82198 | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Danio rerio | - |
- |
- |
Mus musculus | P33435 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
MMP13a | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | in a larval zebrafish model, glucose treatment induces sensory axon degeneration, which is mediated by ROS formation in the skin, and ROS-dependent MMP13 activation. Glucose-induced sensory axon degeneration is prevented upon pharmacological inhibition of ROS with N-acetylcysteine, and upon pharmacological MMP13 inhibition | Danio rerio |
physiological function | neuropathy is reversed upon injection of MMP13 inhibitor into obese mice on a high-fat/high sugar diet | Mus musculus |