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BRENDA support

Literature summary for 3.4.24.B4 extracted from

  • Waldron, A.L.; Schroder, P.A.; Bourgon, K.L.; Bolduc, J.K.; Miller, J.L.; Pellegrini, A.D.; Dubois, A.L.; Blaszkiewicz, M.; Townsend, K.L.; Rieger, S.
    Oxidative stress-dependent MMP-13 activity underlies glucose neurotoxicity (2018), J. Diabetes Complicat., 32, 249-257 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
CL-82198
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Mus musculus P33435
-
-

Synonyms

Synonyms Comment Organism
MMP13a
-
Mus musculus

General Information

General Information Comment Organism
physiological function in a larval zebrafish model, glucose treatment induces sensory axon degeneration, which is mediated by ROS formation in the skin, and ROS-dependent MMP13 activation. Glucose-induced sensory axon degeneration is prevented upon pharmacological inhibition of ROS with N-acetylcysteine, and upon pharmacological MMP13 inhibition Danio rerio
physiological function neuropathy is reversed upon injection of MMP13 inhibitor into obese mice on a high-fat/high sugar diet Mus musculus