Literature summary for 3.4.24.B4 extracted from

Vicini, P.; Crasc�, L.; Incerti, M.; Ronsisvalle, S.; Cardile, V.; Panico, A.
Benzisothiazolyliminothiazolidin-4-ones with chondroprotective properties: Searching for potent and selective inhibitors of MMP-13 (2011), ChemMedChem, 6, 1199-1202.

Search for more literature for 3.4.24.B4

Inhibitors

Inhibitors	Comment	Organism	Structure
(2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-(2-methoxybenzylidene)-1,3-thiazolidin-4-one	-	Homo sapiens
(2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-(3-methoxybenzylidene)-1,3-thiazolidin-4-one	-	Homo sapiens
2-(benzo[d]isothiazol-3-ylimino)-5-(4-methoxybenzylidene)thiazolidin-4-one	potent and selective MMP-13 inhibitor	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains zinc	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	-	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000036	-	pH and temperature not specified in the publication	Homo sapiens	2-(benzo[d]isothiazol-3-ylimino)-5-(4-methoxybenzylidene)thiazolidin-4-one
0.1	-	IC50 above 0.1 mM, pH and temperature not specified in the publication	Homo sapiens	(2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-(3-methoxybenzylidene)-1,3-thiazolidin-4-one
0.1	-	IC50 above 0.1 mM, pH and temperature not specified in the publication	Homo sapiens	(2Z,5E)-2-(1,2-benzothiazol-3-ylimino)-5-(2-methoxybenzylidene)-1,3-thiazolidin-4-one

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)