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Literature summary for 3.4.24.B4 extracted from

  • Kimura, H.; Yukitake, H.; Suzuki, H.; Tajima, Y.; Gomaibashi, K.; Morimoto, S.; Funabashi, Y.; Yamada, K.; Takizawa, M.
    The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death (2009), J. Pharmacol. Sci., 110, 201-211.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
real-time quantitative PCR MMP-13 expression analysis, overview Homo sapiens
real-time quantitative PCR MMP-13 expression analysis, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information MMP-13 activity is not directly inhibited by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 Homo sapiens
additional information MMP-13 activity is not directly inhibited by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
cartilage
-
Homo sapiens
-
cartilage
-
Rattus norvegicus
-
chondrocyte articular Homo sapiens
-
chondrocyte articular Rattus norvegicus
-
commercial preparation recombinant MMP-13 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5 + H2O colorimetric substrate Homo sapiens ?
-
?
Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5 + H2O colorimetric substrate Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
MMP-13
-
Homo sapiens
MMP-13
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus interleukin-1beta induces MMP-13 expression, mediated by extracellular signal-regulated protein kinase, p38 kinase, and c-Jun N-terminal kinase of the MAPK family signal transduction molecules. The interleukin-1beta-induced expression of MMP-13 is selectively inhibited by ERK MAPK pathway inhibitor U0126 and by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 in vivo, overview up
Homo sapiens interleukin-1beta induces MMP-13 expression, mediated by extracellular signal-regulated protein kinase, p38 kinase, and c-Jun N-terminal kinase of the MAPK family signal transduction molecules. The interleukin-1beta-induced expression of MMP-13 is selectively inhibited by ERK MAPK pathway inhibitor U0126, and by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1, overview. It is also less selectively inhibited by the p38 kinase inhibitor SB203580 and the JNK inhibitor SP600125 up

General Information

General Information Comment Organism
physiological function tMMP-13 is responsible for cartilage proteoglycan degradation in rat synovial joints Rattus norvegicus