Cloned (Comment) | Organism |
---|---|
real-time quantitative PCR MMP-13 expression analysis, overview | Homo sapiens |
real-time quantitative PCR MMP-13 expression analysis, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | MMP-13 activity is not directly inhibited by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 | Homo sapiens | |
additional information | MMP-13 activity is not directly inhibited by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | - |
Homo sapiens | - |
cartilage | - |
Rattus norvegicus | - |
chondrocyte | articular | Homo sapiens | - |
chondrocyte | articular | Rattus norvegicus | - |
commercial preparation | recombinant MMP-13 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5 + H2O | colorimetric substrate | Homo sapiens | ? | - |
? | |
Ac-PLG-[2-mercapto-4-methyl-pentanoyl]-LG-OC2H5 + H2O | colorimetric substrate | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Homo sapiens |
MMP-13 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | interleukin-1beta induces MMP-13 expression, mediated by extracellular signal-regulated protein kinase, p38 kinase, and c-Jun N-terminal kinase of the MAPK family signal transduction molecules. The interleukin-1beta-induced expression of MMP-13 is selectively inhibited by ERK MAPK pathway inhibitor U0126 and by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1 in vivo, overview | up |
Homo sapiens | interleukin-1beta induces MMP-13 expression, mediated by extracellular signal-regulated protein kinase, p38 kinase, and c-Jun N-terminal kinase of the MAPK family signal transduction molecules. The interleukin-1beta-induced expression of MMP-13 is selectively inhibited by ERK MAPK pathway inhibitor U0126, and by the imidazo[5,1-c][1,4]thiazine derivative ITZ-1, overview. It is also less selectively inhibited by the p38 kinase inhibitor SB203580 and the JNK inhibitor SP600125 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | tMMP-13 is responsible for cartilage proteoglycan degradation in rat synovial joints | Rattus norvegicus |