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Literature summary for 3.4.24.B4 extracted from

  • Tabuchi, S.; Sakuta, T.; Oyama, T.; Tokuda, M.; Tatsuyama, S.; Kajihara, T.; Nagaoka, S.; Beppu, M.; Sugihara, K.; Ikebe, T.; Shirasuna, K.; Torii, M.
    Runt-related gene 2 is involved in the inhibition of matrix metalloproteinase-13 expression by roxithromycin in human gingival epithelial cell cultures (2009), J. Periodontal Res., 44, 283-288.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
MMP-13 real-time RT-PCR expression analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens MMP-13 has wide substrate specificity compared with other MMPs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Ca9-22 cell
-
 Homo sapiens
-
epithelial cell
-
 Homo sapiens
-
gingival epithelium MMP-13 real-time RT-PCR expression analysis, overview Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MMP-13 has wide substrate specificity compared with other MMPs Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-13
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens Roxithromycin suppresses the expression of MMP-13 mRNA not only in Ca9-22 cells, but also in other human epithelial cell lines. Roxithromycin strongly inhibits the expression of Runx2 mRNA. Furthermore, Runx2 siRNA inhibits the induction of MMP-13 in Ca9-22 cells down

General Information

General Information Comment Organism
physiological function MMP-13 in involved in periodontitis Homo sapiens