Any feedback?
Literature summary for 3.4.24.B4 extracted from
- Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation (2009), FEBS Lett., 583, 1141-1146.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in C3H10T1/2 cells | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| osteoblast | - |
Rattus norvegicus | - |
| UMR-106-01 cell | - |
Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-13 | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | parathyroid hormone acts via protein kinase A to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter. Runx2 is phosphorylated on Ser28 and Thr340 after 8-bromo cyclic adenosine monophosphate treatment. Runx2 construct having mutations at three phosphorylation sites, S28, S347 and T340, is unable to stimulate MMP-13 promoter activity | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | MMP-13 plays a critical role in parathyroid hormone-induced bone resorption | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
