Cloned (Comment) | Organism |
---|---|
expressed in C3H10T1/2 cells | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoblast | - |
Rattus norvegicus | - |
UMR-106-01 cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | parathyroid hormone acts via protein kinase A to phosphorylate and stimulate the transactivation of Runx2 for MMP-13 promoter. Runx2 is phosphorylated on Ser28 and Thr340 after 8-bromo cyclic adenosine monophosphate treatment. Runx2 construct having mutations at three phosphorylation sites, S28, S347 and T340, is unable to stimulate MMP-13 promoter activity | up |
General Information | Comment | Organism |
---|---|---|
physiological function | MMP-13 plays a critical role in parathyroid hormone-induced bone resorption | Rattus norvegicus |