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Literature summary for 3.4.24.B4 extracted from

  • Nannuru, K.C.; Futakuchi, M.; Varney, M.L.; Vincent, T.M.; Marcusson, E.G.; Singh, R.K.
    Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface (2010), Cancer Res., 70, 3494-3504.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine MMP13 is a potential therapeutic target for breast cancer bone metastasis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information knockdown of MMP13 expression at the tumor-bone interface leads to significant reduction in bone destruction and in the number of activated osteoclasts at the tumor-bone interface Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
Balb/c mice
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
Mus musculus
-
breast cancer cell expression of MMP13 in tumors Mus musculus
-
Cl-66 cell mammary tumor-derived cell line Mus musculus
-
additional information MMP13 is upregulated at the breast tumor-bone interface, gene expression profiling, overview Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gelatin + H2O zymographic assay Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
MMP-13
-
Mus musculus
MMP13
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Mus musculus

General Information

General Information Comment Organism
additional information kinetics of MMP13 mRNA expression and tumor-induced osteolysis Mus musculus
physiological function functional role of MMP13 in tumor-induced osteolysis, MMP-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface Mus musculus