Application | Comment | Organism |
---|---|---|
medicine | MMP13 is a potential therapeutic target for breast cancer bone metastasis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of MMP13 expression at the tumor-bone interface leads to significant reduction in bone destruction and in the number of activated osteoclasts at the tumor-bone interface | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
breast cancer cell | expression of MMP13 in tumors | Mus musculus | - |
Cl-66 cell | mammary tumor-derived cell line | Mus musculus | - |
additional information | MMP13 is upregulated at the breast tumor-bone interface, gene expression profiling, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gelatin + H2O | zymographic assay | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-13 | - |
Mus musculus |
MMP13 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | kinetics of MMP13 mRNA expression and tumor-induced osteolysis | Mus musculus |
physiological function | functional role of MMP13 in tumor-induced osteolysis, MMP-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface | Mus musculus |