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Literature summary for 3.4.24.B4 extracted from

  • Ma, O.; Cai, W.W.; Zender, L.; Dayaram, T.; Shen, J.; Herron, A.J.; Lowe, S.W.; Man, T.K.; Lau, C.C.; Donehower, L.A.
    MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression (2009), Cancer Res., 69, 2559-2567.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
matrix metalloproteinase gene MMP13 and the antiapoptotic genes Birc2, cIAP1, and Birc3, cIAP2, form an amplicon located on chromosome 11q22, and show elevated expression in osteosarcomas Homo sapiens
matrix metalloproteinase gene MMP13 and the antiapoptotic genes Birc2, cIAP1, and Birc3, cIAP2, form an amplicon located on chromosome 9A1, and show elevated expression in osteosarcomas Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
osteosarcoma cell overexpression of MMP13 Mus musculus
-
osteosarcoma cell overexpression of MMP13 Homo sapiens
-

Synonyms

Synonyms Comment Organism
MMP13
-
Mus musculus
MMP13
-
Homo sapiens

General Information

General Information Comment Organism
additional information down-regulation of MMP13, Birc2, or Birc3 results in reduced tumor growth when transplanted into immunodeficient recipient mice, high MMP13 expression enhances osteosarcoma cell survival Mus musculus
additional information down-regulation of MMP13, Birc2, or Birc3 results in reduced tumor growth, while high MMP13 expression enhances osteosarcoma cell survival Homo sapiens