Literature summary for 3.4.24.B4 extracted from

Mak, I.W.; Cowan, R.W.; Popovic, S.; Colterjohn, N.; Singh, G.; Ghert, M.
Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone (2009), Bone, 45, 377-386.

Search for more literature for 3.4.24.B4

Cloned(Commentary)

Cloned (Comment)	Organism
MMP13 real-time RT-PCR expression analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P45452	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
giant cell tumor cell	MMP-13 is the principal proteinase expressed by the mesenchymal stromal cells of giant cell tumor	Homo sapiens	-
additional information	immunohistochemic MMP13 expression analysis	Homo sapiens	-
stromal cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	siRNA knockdown of transcription factor Runx2 decreases MMP-13 expression in giant cell tumor stromal cells	down
Homo sapiens	the Runx2 transcription factor is known to have a binding site in the MMP-13 promoter region and activates MMP-13 expression constitutively in giant cell tumor cells. Inhibition of the ERK and JNK signaling pathways inhibits the upregulation of MMP-13 in these cells	up

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Release 2023.1 (January 2023)