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Literature summary for 3.4.24.B4 extracted from

  • Lu, D.Y.; Leung, Y.M.; Cheung, C.W.; Chen, Y.R.; Wong, K.L.
    Glial cell line-derived neurotrophic factor induces cell migration and matrix metalloproteinase-13 expression in glioma cells (2010), Biochem. Pharmacol., 80, 1201-1209.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information MMP-13 downregulation by siRNA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Homo sapiens
Zn2+ dependent on Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioma cell
-
Homo sapiens
-
U-251 cell
-
Homo sapiens
-
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bovine type B gelatin + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
MMP-13
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
assay at room temperature Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens GDNF-induced MMP-13 expression and glioma migration are attenuated by MEK/extracellular signal-regulating kinase and c-Jun N-terminal protein kinase inhibitors, PD98059 and SP600125, as well as ERK and JNKdominant-negative mutants. AP-1 inhibitors, tanshinone IIA and curcumin, also reduce GDNF-induced glioma cell migration additional information
Homo sapiens glial cell line-derived neurotrophic factor, GDNF, induces cell migration and MMP-13 expression in glioma cells up