Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide | i.e. PF152, a potent and highly selective MMP-13 inhibitor, that binds the S1' active site pocket of the enzyme, is not a ligand to the catalytic zinc atom, and dose-dependently decreases cartilage degradation ex vivo. PF152 treatment of osteoarthritis dogs reduces cartilage lesions and decreased biomarkers of type II collagen and aggrecan degradation | Canis lupus familiaris | |
N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide | i.e. PF152, a non-hydroxamic acid and a potent and highly selective MMP-13 inhibitor, that binds the S1' active site pocket of the enzyme and is not a ligand to the catalytic zinc atom | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular matrix | - |
Homo sapiens | 31012 | - |
extracellular matrix | - |
Canis lupus familiaris | 31012 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
type II collagen + H2O | Homo sapiens | - |
? | - |
? | |
type II collagen + H2O | Canis lupus familiaris | - |
? | - |
? | |
type II gelatin + H2O | Homo sapiens | - |
? | - |
? | |
type II gelatin + H2O | Canis lupus familiaris | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Canis lupus familiaris | - |
mature female beagles with osteoarthritis | - |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cartilage | articular | Homo sapiens | - |
cartilage | articular | Canis lupus familiaris | - |
synovial fluid | - |
Homo sapiens | - |
synovial fluid | - |
Canis lupus familiaris | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
MCA-Arg-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-Glu-Arg-NH2 + H2O | - |
Canis lupus familiaris | ? | - |
? | |
type II collagen + H2O | - |
Homo sapiens | ? | - |
? | |
type II collagen + H2O | - |
Canis lupus familiaris | ? | - |
? | |
type II collagen + H2O | full-length substrate from bovine | Homo sapiens | ? | - |
? | |
type II collagen + H2O | full-length substrate from bovine | Canis lupus familiaris | ? | - |
? | |
type II gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
type II gelatin + H2O | - |
Canis lupus familiaris | ? | - |
? | |
type II gelatin + H2O | full-length substrate from bovine | Homo sapiens | ? | - |
? | |
type II gelatin + H2O | full-length substrate from bovine | Canis lupus familiaris | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase 13 | - |
Homo sapiens |
matrix metalloproteinase 13 | - |
Canis lupus familiaris |
MMP-13 | - |
Homo sapiens |
MMP-13 | - |
Canis lupus familiaris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000084 | - |
N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide | pH not specified in the publication, temperature not specified in the publication | Canis lupus familiaris | |
0.0000015 | - |
N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide | pH not specified in the publication, temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000012 | - |
pH not specified in the publication, temperature not specified in the publication, versus full-length bovine type II collagen | Homo sapiens | N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide | |
0.000002 | - |
pH not specified in the publication, temperature not specified in the publication, versus full-length bovine type II gelatin | Homo sapiens | N-(4-fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide |