Literature summary for 3.4.24.B4 extracted from

Hayashida, M.; Okazaki, K.; Fukushi, J.; Sakamoto, A.; Iwamoto, Y.
CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritis (2009), Arthritis Rheum., 60, 708-716.

Search for more literature for 3.4.24.B4

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular matrix	-	Homo sapiens	31012	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
C-28/I2 cell	-	Homo sapiens	-
cartilage	obtained from patients with rheumatoid arthritis and osteoarthritis. CCAAT/enhancer binding protein beta, i.e. C/EBPbeta, and MMP-13 expressions are colocalized in chondrocytes in arthritic cartilage	Homo sapiens	-
chondrocyte	articular	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	interleukin-1beta and tumor necrosis factor-alpha induce MMP-13 expression. When CCAAT/enhancer binding protein beta, i.e. C/EBPbeta and liver-enriched activator protein, LAP, are overexpressed in C-28/I2 cells, endogenous MMP-13 expression is stimulated up to 32fold. Both C/EBPbeta and AP-1 are essential regulators of the MMP-13 promoter	up

General Information

General Information	Comment	Organism
additional information	MMP-13 expression is increased in rheumatoid arthritis and osteoarthritis	Homo sapiens
physiological function	MMP-13 efficiently degrades proteoglycans and type II collagen in articular cartilage and may therefore play a central role in articular cartilage degradation	Homo sapiens

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Release 2023.1 (January 2023)