Literature summary for 3.4.24.B4 extracted from

Rasheed, Z.; Anbazhagan, A.N.; Akhtar, N.; Ramamurthy, S.; Voss, F.R.; Haqqi, T.M.
Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes (2009), Arthritis Res. Ther., 11, R71.

Search for more literature for 3.4.24.B4

Cloned(Commentary)

Cloned (Comment)	Organism
real-time quantitative PCR MMP-13 expression analysis	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular matrix	-	Homo sapiens	31012	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	-	Homo sapiens	-
chondrocyte	from osteoarthritis cartilage	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-13	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	epigallocatechin-3-gallate, EGCG, from Camellia sinensis inhibits advanced glycation end product-induced expression of matrix metalloproteinase-13 in chondrocytes involving suppression of p38-MAPK and JNK activation, overview	down
Homo sapiens	MMP-13 expression is induced by advanced glycation end products, e.g. pentosidine or N3-carboxymethyllysine, the induction is significantly inhibited by SB202190 and SP600125	up

General Information

General Information	Comment	Organism
additional information	age-related accumulation of advanced glycation end products can activate chondrocytes and induce the production of proinflammatory cytokines and matrix metalloproteinases	Homo sapiens
physiological function	MMP-13 acts as an inflammatory mediator in age-related osteoarthritis	Homo sapiens

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Release 2023.1 (January 2023)