Literature summary for 3.4.24.B4 extracted from

Heikkilae, P.; Teronen, O.; Moilanen, M.; Konttinen, Y.T.; Hanemaaijer, R.; Laitinen, M.; Maisi, P.; van der Pluijm, G.; Bartlett, J.D.; Salo, T.; Sorsa, T.
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines (2002), Anticancer Drugs, 13, 245-254.

Inhibitors

Inhibitors	Comment	Organism	Structure
alendronate	inhibits the in vitro invasion and random cell migration, 99% inhibition at 0.4 mM and physiological Ca2+-concentration, 67% inhibition at 0.4 mM and high Ca2+-concentration	Homo sapiens
clodronate	77% inhibition at 0.4 mM and physiological Ca2+-concentration, 35.7% inhibition at 0.4 mM and high Ca2+-concentration	Homo sapiens

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
protein + H2O	Homo sapiens	-	peptides	-	?

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification	Comment	Organism
proteolytic modification	autoactivation	Homo sapiens

Source Tissue	Comment	Organism	Textmining
C81-61 cell	melanoma cell line	Homo sapiens	-
HT-1080 cell	fibrosaocoma cell line	Homo sapiens	-

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
beta-casein + H2O	-	Homo sapiens	?	-	?
protein + H2O	-	Homo sapiens	peptides	-	?

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.8	-	assay at	Homo sapiens