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Literature summary for 3.4.24.B12 extracted from

  • Atobe, M.; Maekawara, N.; Ishiguro, N.; Sogame, S.; Suenaga, Y.; Kawanishi, M.; Suzuki, H.; Jinno, N.; Tanaka, E.; Miyoshi, S.
    A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 2106-2110.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-benzyl-4-((4-(4-chlorophenoxy) phenyl)-sulfonyl)-N-hydroxypiperidine-4-carboxamide multi-MMP inhibitor Homo sapiens
3-[2-[(Z)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-4-(pyridin-2-yl)-1,3-thiazol-5-yl]propanoic acid inhibits the spontaneous aggrecan degradation in IL-1-stimulated bovine cartilage, shows good selectivity over other metalloproteases; inhibits the spontaneous aggrecan degradation in IL-1-stimulated bovine cartilage, shows good selectivity over other metalloproteases Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens Q9UNA0
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00023
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[2-[(Z)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-4-(pyridin-2-yl)-1,3-thiazol-5-yl]propanoic acid
0.00042
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 1-benzyl-4-((4-(4-chlorophenoxy) phenyl)-sulfonyl)-N-hydroxypiperidine-4-carboxamide
0.023
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-[2-[(Z)-(4-oxo-1,3-thiazolidin-2-ylidene)methyl]-4-(pyridin-2-yl)-1,3-thiazol-5-yl]propanoic acid