Literature summary for 3.4.24.B12 extracted from

Kumar, S.; Sharghi-Namini, S.; Rao, N.; Ge, R.
ADAMTS5 functions as an anti-angiogenic and anti-tumorigenic protein independent of its proteoglycanase activity (2012), Am. J. Pathol., 181, 1056-1068.

Search for more literature for 3.4.24.B12

Application

Application	Comment	Organism
medicine	overexpression of full-length ADAMTS5 suppresses B16 melanoma growth in mice. The reduced tumor growth is correlated with diminished tumor angiogenesis, together with reduced tumor cell proliferation and increased tumor cell apoptosis	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
transfection of B16F1/B16F10 mouse melanoma cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E411A	active site mutant, presents similar tumor suppression activity as wild-type enzyme	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

General Information

General Information	Comment	Organism
physiological function	overexpression of full-length ADAMTS5 suppresses B16 melanoma growth in mice. The reduced tumor growth is correlated with diminished tumor angiogenesis, together with reduced tumor cell proliferation and increased tumor cell apoptosis. Catalytically active ADAMTS5 proteolytic fragment also suppresses angiogenesis in vitro. The catalytic activity of ADAMTS5 is dispensable for its anti-tumorigenic function. ADAMTS5 inhibits B16 tumorigenesis through its TSR1 by suppressing tumor angiogenesis	Homo sapiens

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Release 2023.1 (January 2023)