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Literature summary for 3.4.24.B12 extracted from
- In vitro inhibition of aggrecanase activity by tetracyclines and proteoglycan loss from osteoarthritic human articular cartilage (2010), J. Orthop. Res., 28, 828-833.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| doxycycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens |  |
| minocycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
| tetracycline | dose-dependently inhibits the activity of rhADAMTS4 in vitro | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aggrecan-interglobular domain + H2O | an aggrecan peptide with the N-terminal sequence ARGSVIL is released and quantified | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAMTS5 | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0707 | - |
pH and temperature not specified in the publication | Homo sapiens | doxycycline | |
| 0.111 | - |
pH and temperature not specified in the publication | Homo sapiens | minocycline | |
| 0.899 | - |
pH and temperature not specified in the publication | Homo sapiens | tetracycline | |
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Release 2023.1 (January 2023)
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